Interoperability, as defined by is “the ability to exchange and use information…” Interoperability as applied to immunization record exchange between electronic health record (EHR) systems and statewide immunization information systems (IIS) means the ability to share patient immunization records electronically through HL7 standard communication protocols.

Immunization information systems (IIS), or registries, help providers and families by consolidating immunization information into one reliable source. They also save money by ensuring that children get only the vaccines they need and improve office efficiency by reducing the time needed to gather and review immunization records. Public health agencies use IIS to conduct surveillance, maintain high immunization coverage rates for the population, and for outbreak management and emergency response.

The Arizona State Immunization Information System (ASIIS) has developed an interoperability engine that will promote this meaningful exchange of patient and immunization record information between ASIIS and EHRs at immunization-reporting organizations (practices, hospitals, and clinics).

Interoperability with ASIIS - How can you get started?
The electronic exchange of “meaningful use” immunization data is enabled through the incorporation of data and messaging standards. Health Level Seven (HL7) is an accredited, nationally recognized standard for electronic data exchange for clinical and administrative messages in healthcare environments. Arizona's immunization registry, ASIIS, will support meaningful use stage 2 compliant data exchanges with EHR systems that have the capability to exchange Immunization data using HL7 version 2.5.1. HL7 version 2.3.1 may only be used to attest for meaningful use stage 1. The Centers for Disease Control and Prevention (CDC) has published an implementation guide for immunization transactions for version 2.5.1 of HL7 which should be used by providers seeking to establish an interface with ASIIS. Providers can interface electronically from their EHR to the ASIIS application and transfer patient and immunization record information. If interested, please complete this Initial Interest Form and send it to or fax it to the number provided on the form. Submission of this Initial Interest Form does not guarantee that ASIIS will be able to set you up with a data exchange immediately. You will be prioritized and will hear back from the ASIIS office in a couple of days.

Please contact the Arizona Immunization Program Office ASIIS Hotline at 877-491-5741 or if you have any questions.

Why exchange data with an IIS?
Provider organizations from across the state are mandated by ARS §35-136, effective January 1, 1998 to submit immunization records to ASIIS. In 2009, another statute was added that requires pharmacist-administered vaccines given to adults also be reported to ASIIS. There are a number of good reasons why exchanging data electronically between an IIS and other systems (especially an EHR) is desirable: